USC vs. Notre Dame picks, predictions: Week 13 college football odds, spread, lines

The greatest intersectional rivalry in sports heats up this season as Notre Dame and USC meet in a game loaded with College Football Playoff implications.

After a sluggish early part of the season, Marcus Freeman’s first as head coach, Notre Dame has rebounded by winning five straight games, including three against the class of the ACC, and two of those against the teams that will play for that league’s championship, in North Carolina and Clemson.

Lincoln Riley has also made serious waves in his first season on the job at USC, coming in with a 10-1 overall record, fresh off a statement win over rival UCLA on the road, and having clinched a berth in the Pac-12 Championship Game.

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